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KMID : 0604520150410040401
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Journal of the Society of Cosmetic Scientists of Korea
2015 Volume.41 No. 4 p.401 ~ p.411
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Wound Healing Effect of Low Molecular PDRN on Experimental Surgical Excision Rat Model
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Yun Jong-Kuk
Yoon Hye-Eun
Park Jeong-Kyu
Kim Mi-Ryeo
Kim Dae-Ik
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Abstract
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This study was performed to investigate the wound healing effect of skin regeneration cosmetics utilizing low molecular weight Polydeoxynucleotide (PDRN). High purity PDRN was prepared from salmon testes poly-deoxyribonucleotide through protein and toxin removal process and molecular weight reduction. In order to evaluate the wound healing effect of PDRN in SD rats, 4 sites of dorsal skin of each animal were excised by using biopsy punch and 500 μL of test solution was topically applied once daily for 4 weeks. The tissue changes were observed for every week during the application periods. After applying the PDRN to the wound, the skin was cut flower and contraction of the wounds more quickly, and the coating of PDRN in the wound area was reduced significantly as compared to the positive control group Fucidinⓡ applied. The microscopic observation of stained tissue showed that a positive control was most rapid in re-epithelialization ability followed by the PH group, PDRN group, HA group. In addition, transforming growth factor (TGF-β) and vascular endothelial growth factor (VEGF), such as in the growth factor was similar to the results of staining of tissue lesions. In conclusion, it is determined that the low molecular weight PDRN has the therapeutic effect to the wound, and could be used as a functional material of cosmetics and medical industries.
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KEYWORD
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PDRN, polydeoxyribonucleotide, cosmeceuticals, anti-inflammation, wound healing, wound repair
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